Late endosome to vacuole transport via multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Late endosome to vacuole transport via multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOPX, RN7SL569P, and ITFG2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to vacuole transport via multivesicular body sorting pathway activity versus HOPX in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HOPX →	+1.732	+0.190	<.001	<.001	3	4
HNSC	RN7SL569P →	-0.641	-0.131	.003	.002	3	4
UCEC	ITFG2-AS1 →	-0.619	-0.152	.004	.008	3	4
COAD	MFSD13A →	-0.357	-0.187	.008	.006	3	4
PDAC	MBOAT2 →	+0.692	+0.214	<.001	<.001	3	4
LUAD	PARP11 →	-0.294	-0.125	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032511 vs HOPX — HNSC

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