Late endosome to vacuole transport via multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Late endosome to vacuole transport via multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF689, NDRG3, and PDSS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to vacuole transport via multivesicular body sorting pathway activity versus ZNF689 in LUNG_SCLC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF689 →	+0.623	+0.960	.002	.001	3	6
LIVER	NDRG3 →	+0.557	+1.181	.006	.003	3	5
BONE	PDSS2 →	+0.670	+1.459	.001	.001	3	5
CNS	HMOX2 →	+0.622	+0.978	.001	<.001	3	4
CNS	USP7 →	+0.461	+0.980	.001	<.001	3	4
BLOOD_Lymphoma	ROBO3 →	-2.051	-0.897	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032511 vs ZNF689 — LUNG_SCLC

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