Maintenance of protein location in cell

Across TCGA patient cohorts, RNA activity of the Maintenance of protein location in cell pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAB3, FLI1, and HSH2D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in cell activity versus GAB3 in LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAB3 →	+0.623	+0.223	<.001	<.001	3	5
LSCC	FLI1 →	+0.530	+0.188	<.001	<.001	3	5
HNSC	HSH2D →	+0.813	+0.112	.004	.003	3	4
PDAC	GRAP2 →	+0.370	+0.077	<.001	.001	3	4
GBM	CD40 →	+1.505	+0.187	<.001	<.001	3	4
PDAC	TLR8 →	+0.430	+0.068	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032507 vs GAB3 — LUAD

Explore this scatter interactively →