Maintenance of protein location in cell

Across TCGA cell cohorts, RNA activity of the Maintenance of protein location in cell pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS45, SUOX, and NMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in cell activity versus VPS45 in BREAST (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VPS45 →	-0.855	-0.225	.002	.005	3	6
PANCREAS	SUOX →	-0.885	-0.162	.004	.005	3	6
OVARY	NMT2 →	+1.123	+0.215	.001	<.001	3	6
BONE	NOSTRIN →	-0.964	-0.223	.002	<.001	3	6
LUNG_SCLC	SMAD9 →	-1.790	-0.143	.002	.001	3	5
SKIN	BCL10 →	+0.535	+0.188	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032507 vs VPS45 — BREAST

Explore this scatter interactively →