Cytokinetic process

Across TCGA patient cohorts, RNA activity of the Cytokinetic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG5-AS1, FLNB-AS1, and FNBP4, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytokinetic process activity versus SPAG5-AS1 in DLBC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	SPAG5-AS1 →	+0.579	+0.064	<.001	.003	3	30
PAAD	FLNB-AS1 →	+0.772	+0.036	<.001	<.001	3	30
UVM	FNBP4 →	+1.106	+0.019	<.001	<.001	3	29
ACC	RAD51AP1 →	+1.917	+0.053	<.001	<.001	3	29
LIHC	DROSHA →	+0.762	+0.047	<.001	<.001	3	29
DLBC	NKTR →	+1.494	+0.070	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032506 vs SPAG5-AS1 — DLBC

Explore this scatter interactively →