Cytokinetic process

Across TCGA patient cohorts, RNA activity of the Cytokinetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1A, PLEK2, and CAVIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytokinetic process activity versus ERO1A in PDAC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ERO1A →	+0.681	+0.187	.001	.001	3	6
LSCC	PLEK2 →	+0.819	+0.294	<.001	.009	3	5
PDAC	CAVIN1 →	+0.601	+0.235	<.001	<.001	3	5
LSCC	AHNAK2 →	+1.136	+0.394	<.001	.006	3	5
LSCC	PLPP4 →	+0.747	+0.336	<.001	.002	3	5
HNSC	KCTD11 →	+0.849	+0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032506 vs ERO1A — PDAC

Explore this scatter interactively →