Cytokinetic process

Across TCGA cell cohorts, RNA activity of the Cytokinetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS4, METTL21A, and LONRF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytokinetic process activity versus DHRS4 in URINARY_TRACT (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DHRS4 →	+1.275	+0.376	.001	.001	3	5
BREAST	METTL21A →	+0.785	+0.184	.007	.005	3	5
SKIN	LONRF3 →	+1.450	+0.268	<.001	.001	3	5
BONE	MRPL16 →	+0.688	+0.301	<.001	<.001	3	4
STOMACH	PRKCA →	+1.512	+0.222	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	ARFRP1 →	+0.942	+0.146	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032506 vs DHRS4 — URINARY_TRACT

Explore this scatter interactively →