Response to peptidoglycan

Across TCGA patient cohorts, RNA activity of the Response to peptidoglycan pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1LG2, BIN2, and CD80, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to peptidoglycan activity versus PDCD1LG2 in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PDCD1LG2 →	+0.474	+0.593	.001	<.001	3	7
GBM	BIN2 →	+0.523	+0.701	<.001	<.001	3	6
CCRCC	CD80 →	+0.665	+0.631	<.001	<.001	3	6
LSCC	CCRL2 →	+0.672	+0.747	<.001	<.001	3	6
GBM	LILRB2 →	+0.859	+0.824	<.001	<.001	3	6
GBM	SLA →	+0.898	+0.725	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032494 vs PDCD1LG2 — LSCC

Explore this scatter interactively →