Response to bacterial lipoprotein

Across TCGA cell cohorts, RNA activity of the Response to bacterial lipoprotein pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN3, KIF11, and MAML2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBN3 grouped by Response to bacterial lipoprotein-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FBN3 →	-0.184	-1.434	.008	.003	3	3
PANCREAS	KIF11 →	+0.502	+0.182	.005	.001	3	3
PANCREAS	MAML2 →	+0.234	+0.224	.004	<.001	3	3
LARGE_INTESTINE	ANKRD26 →	+0.175	+0.782	<.001	.004	3	3
BONE	CCL26 →	+0.375	+0.260	<.001	.001	3	3
BLOOD_Myeloma	GALNT6 →	+0.580	+2.009	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBN3 by Response to bacterial lipoprotein activity — SOFT_TISSUE

Explore this box plot interactively →