Regulation of Cdc42 protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Cdc42 protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL6A3, IGFBP7, and TIMP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Cdc42 protein signal transduction activity versus COL6A3 in GBM (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A3 →	+0.823	+0.095	<.001	<.001	3	9
CCRCC	IGFBP7 →	+0.586	+0.068	<.001	.002	3	8
BRCA	TIMP2 →	+0.789	+0.097	<.001	<.001	3	8
OV	ACTN1 →	+0.450	+0.095	<.001	<.001	3	8
BRCA	VIM →	+0.447	+0.073	<.001	<.001	3	8
GBM	COL1A1 →	+0.671	+0.083	.008	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032489 vs COL6A3 — GBM

Explore this scatter interactively →