Regulation of Cdc42 protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Cdc42 protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIA, SRP14P4, and IER5L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Cdc42 protein signal transduction activity versus NFIA in OV (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NFIA →	-0.553	-0.246	.001	<.001	3	3
OV	SRP14P4 →	-0.684	-0.258	.001	<.001	3	3
LSCC	IER5L →	+0.539	+0.300	<.001	.002	3	3
PDAC	AAK1 →	-0.201	-0.146	.002	.007	3	3
PDAC	ATP10B →	-1.171	-0.175	<.001	.004	3	3
PDAC	PCBD2 →	-0.217	-0.168	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032489 vs NFIA — OV

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