Regulation of Cdc42 protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Cdc42 protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC15, RGPD8, and SDSL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC15 grouped by Regulation of Cdc42 protein signal transduction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAJC15 →	-2.098	-0.986	.005	.003	2	5
LUNG_NSCLC_LUAD	RGPD8 →	-0.665	-0.307	.001	.007	3	4
LARGE_INTESTINE	SDSL →	-0.764	-0.783	.004	.007	3	3
BONE	TNFAIP6 →	-5.071	-1.476	<.001	.001	3	3
CNS	TMED4 →	-0.582	-0.866	.007	.006	3	3
LIVER	NAB2 →	-0.698	-0.520	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC15 by Regulation of Cdc42 protein signal transduction activity — OVARY

Explore this box plot interactively →