Regulation of Cdc42 protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Cdc42 protein signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF6B, REV3L, and MXRA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATF6B grouped by Regulation of Cdc42 protein signal transduction-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ATF6B →	+0.120	+1.754	.004	<.001	3	5
SOFT_TISSUE	REV3L →	-0.443	-1.821	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MXRA5 →	-0.162	-1.422	.008	<.001	2	4
BREAST	DTD2 →	-0.234	-0.933	.004	.004	3	3
KIDNEY	SLC25A5 →	-0.470	-1.821	.003	<.001	3	3
OVARY	NTF4 →	-0.283	-1.213	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATF6B by Regulation of Cdc42 protein signal transduction activity — URINARY_TRACT

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