Cdc42 protein signal transduction

Across TCGA cell cohorts, RNA activity of the Cdc42 protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF440, ZNF189, and EEF1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF440 grouped by Cdc42 protein signal transduction-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF440 →	+0.874	+0.707	.001	.004	3	5
CNS	ZNF189 →	+0.424	+1.048	.002	.001	3	4
LUNG_SCLC	EEF1D →	-0.845	-1.139	.003	.001	3	4
BREAST	BEX2 →	+1.657	+0.823	.001	.004	3	3
KIDNEY	RPN1 →	-0.956	-1.173	.007	.001	3	3
BLOOD_Leukemia	PCYOX1 →	+0.900	+0.971	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF440 by Cdc42 protein signal transduction activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →