Rap protein signal transduction

Across TCGA patient cohorts, RNA activity of the Rap protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MIPEP, BICD2, and DBN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rap protein signal transduction activity versus MIPEP in BRCA (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIPEP →	-0.271	-0.042	.006	.006	3	7
LUAD	BICD2 →	+0.204	+0.065	<.001	<.001	3	6
OV	DBN1 →	+0.528	+0.041	.001	.002	3	6
GBM	CTNNA1 →	-0.443	-0.069	<.001	<.001	3	6
GBM	STK10 →	+0.286	+0.042	.002	.008	3	6
COAD	ACAP2 →	+0.156	+0.026	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032486 vs MIPEP — BRCA

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