Rap protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rap protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD3, GAREM2, and KDM6B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OTUD3 grouped by Rap protein signal transduction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OTUD3 →	-0.722	-1.056	.004	<.001	3	5
OESOPHAGUS	GAREM2 →	-1.177	-0.815	<.001	.002	3	5
BLOOD_Myeloma	KDM6B →	-1.285	-1.405	.008	.003	3	4
BLOOD_Myeloma	GATAD2B →	-0.965	-1.542	.002	.004	2	5
URINARY_TRACT	OGFRL1 →	+2.228	+1.336	<.001	<.001	3	4
URINARY_TRACT	NNMT →	+5.563	+1.690	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OTUD3 by Rap protein signal transduction activity — OVARY

Explore this box plot interactively →