Rap protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rap protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP2B, RPL11, and MRPL11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rap protein signal transduction activity versus RAP2B in SKIN (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RAP2B →	+1.032	+1.352	.001	<.001	3	8
BONE	RPL11 →	-0.812	-2.200	<.001	<.001	3	4
LUNG_SCLC	MRPL11 →	+0.569	+0.977	.007	.007	3	4
OESOPHAGUS	CDC123 →	-0.604	-0.986	.007	.001	3	3
OESOPHAGUS	KIAA1958 →	-0.701	-0.886	.006	.004	3	3
BLOOD_Lymphoma	TAF1B →	+0.550	+0.781	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032486 vs RAP2B — SKIN

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