Regulation of Rab protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rab protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCY, MAGED4, and TAGLN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AHCY grouped by Regulation of Rab protein signal transduction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AHCY →	+0.668	+1.343	.002	.003	3	3
STOMACH	MAGED4 →	+2.408	+1.249	.005	.003	3	3
SKIN	TAGLN2 →	-0.912	-1.109	.003	.002	3	3
LUNG_NSCLC_LUAD	NOL4L →	+1.136	+1.152	.006	.001	3	3
LUNG_NSCLC_LUSC	QPRT →	+3.360	+1.244	.001	.001	3	3
BREAST	CXXC5 →	+1.685	+0.867	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AHCY by Regulation of Rab protein signal transduction activity — STOMACH

Explore this box plot interactively →