Regulation of Rab protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rab protein signal transduction pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZD6738, JQ12, and I-BRD9, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZD6738 grouped by Regulation of Rab protein signal transduction-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AZD6738 →	-0.893	-0.489	.010	.021	3	2
BLOOD_Leukemia	JQ12 →	-0.839	-0.213	.003	.002	3	1
BLOOD_Leukemia	I-BRD9 →	-0.530	-0.213	.011	.002	3	1
BLOOD_Leukemia	Tipifarnib →	-0.702	-0.213	.021	.002	3	1
BLOOD_Leukemia	eEF2K Inhibitor →	-0.249	-0.236	.037	.005	2	2
BLOOD_Lymphoma	Methotrexate →	+1.939	+0.523	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD6738 by Regulation of Rab protein signal transduction activity — BLOOD_Lymphoma

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