Rab protein signal transduction

Across TCGA patient cohorts, RNA activity of the Rab protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, SEPTIN7, and DNM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rab protein signal transduction activity versus MAP1A in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP1A →	+0.446	+0.076	<.001	<.001	3	5
GBM	SEPTIN7 →	+0.262	+0.078	<.001	<.001	3	4
GBM	DNM1 →	+0.684	+0.082	<.001	<.001	3	4
OV	EIF3K →	-0.244	-0.046	.001	<.001	3	4
GBM	EPB41L3 →	+0.559	+0.067	<.001	<.001	3	4
HNSC	S100A14 →	-0.706	-0.051	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032482 vs MAP1A — GBM

Explore this scatter interactively →