Rab protein signal transduction

Across TCGA patient cohorts, RNA activity of the Rab protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXN, GLS, and NDUFAF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rab protein signal transduction activity versus NXN in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NXN →	-0.648	-0.232	.001	<.001	3	4
BRCA	GLS →	-0.641	-0.306	<.001	<.001	3	3
BRCA	NDUFAF4 →	-0.402	-0.205	<.001	.003	3	3
BRCA	ARHGEF4 →	-0.714	-0.267	<.001	<.001	3	3
BRCA	RARS2 →	-0.273	-0.244	.004	.001	3	3
BRCA	PTPN14 →	-0.730	-0.217	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032482 vs NXN — BRCA

Explore this scatter interactively →