Rab protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rab protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPF3B, CCDC138, and HNRNPF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPF3B grouped by Rab protein signal transduction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UPF3B →	+1.093	+1.373	<.001	<.001	3	5
BLOOD_Leukemia	CCDC138 →	+0.771	+1.213	.001	<.001	3	5
BLOOD_Leukemia	HNRNPF →	+0.610	+1.068	.003	<.001	3	5
LIVER	PLGRKT →	+0.811	+1.491	.009	<.001	3	5
BLOOD_Leukemia	STAG2 →	+0.980	+0.859	.001	.002	3	4
KIDNEY	HBS1L →	+1.275	+1.479	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPF3B by Rab protein signal transduction activity — LUNG_SCLC

Explore this box plot interactively →