Rab protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rab protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMACHC, RPP30, and ST3GAL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rab protein signal transduction activity versus MMACHC in LUNG_SCLC (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MMACHC →	-0.402	-0.137	.004	.003	3	4
OVARY	RPP30 →	-0.728	-0.244	.001	.002	3	4
CNS	ST3GAL6 →	+0.688	+0.236	.006	.001	3	3
LUNG_SCLC	MCM5 →	+0.824	+0.249	<.001	<.001	3	3
LUNG_SCLC	TAB1 →	+0.619	+0.183	<.001	.006	3	3
LUNG_SCLC	RBX1 →	+0.378	+0.150	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032482 vs MMACHC — LUNG_SCLC

Explore this scatter interactively →