Positive regulation of type I interferon production

Across TCGA cell cohorts, RNA activity of the Positive regulation of type I interferon production pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS8L1, CCNA2, and PTAFR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type I interferon production activity versus EPS8L1 in OVARY (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EPS8L1 →	-3.938	-0.288	.002	.001	3	6
LUNG_SCLC	CCNA2 →	+0.726	+0.182	<.001	.001	3	6
URINARY_TRACT	PTAFR →	-3.090	-0.316	.003	.006	3	6
BLOOD_Leukemia	NKIRAS1 →	+0.525	+0.136	<.001	.001	2	7
PANCREAS	COPRS →	+1.311	+0.343	<.001	<.001	3	6
LARGE_INTESTINE	AASS →	+1.249	+0.152	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032481 vs EPS8L1 — OVARY

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