Negative regulation of type I interferon production

Across TCGA patient cohorts, RNA activity of the Negative regulation of type I interferon production pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK10, DOCK2, and CMPK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type I interferon production activity versus DOCK10 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK10 →	+0.399	+0.042	<.001	<.001	3	9
GBM	DOCK2 →	+0.549	+0.067	<.001	<.001	3	9
GBM	CMPK2 →	+0.583	+0.055	<.001	<.001	3	9
UCEC	ANKRD44 →	+0.381	+0.062	<.001	<.001	3	9
GBM	SAMHD1 →	+0.590	+0.074	<.001	<.001	3	8
UCEC	STAT1 →	+0.565	+0.056	.004	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032480 vs DOCK10 — LSCC

Explore this scatter interactively →