Negative regulation of type I interferon production

Across TCGA patient cohorts, RNA activity of the Negative regulation of type I interferon production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP4, LAG3, and RUFY4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type I interferon production activity versus GBP4 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GBP4 →	+1.543	+0.120	<.001	.008	3	6
UCEC	LAG3 →	+0.674	+0.230	.007	.003	3	5
OV	RUFY4 →	+0.762	+0.102	<.001	.004	3	5
HNSC	EPSTI1 →	+1.077	+0.145	<.001	.004	2	5
HNSC	APOBEC3G →	+0.788	+0.173	.004	<.001	3	4
LUAD	GFI1 →	+0.297	+0.129	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032480 vs GBP4 — HNSC

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