Negative regulation of type I interferon production

Across TCGA cell cohorts, RNA activity of the Negative regulation of type I interferon production pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDEM3, CBLB, and PPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDEM3 grouped by Negative regulation of type I interferon production-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EDEM3 →	+0.905	+0.302	.006	.004	3	5
LUNG_NSCLC_LUSC	CBLB →	+1.766	+0.242	.004	.005	3	4
LUNG_NSCLC_LUSC	PPA1 →	-1.093	-0.259	<.001	.003	3	4
BLOOD_Leukemia	SLC45A4 →	+1.519	+0.270	<.001	.001	3	4
URINARY_TRACT	OTUB2 →	+0.635	+0.252	.002	.007	3	4
BLOOD_Leukemia	FPGT →	+1.006	+0.215	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDEM3 by Negative regulation of type I interferon production activity — URINARY_TRACT

Explore this box plot interactively →