Negative regulation of type I interferon production

Across TCGA cell cohorts, RNA activity of the Negative regulation of type I interferon production pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL2, TXNL4A, and PAQR3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type I interferon production activity versus ARL2 in URINARY_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARL2 →	+0.898	+0.425	.001	<.001	3	6
SKIN	TXNL4A →	+0.804	+0.290	.003	.001	2	6
BREAST	PAQR3 →	+0.753	+0.880	.002	.003	3	5
LIVER	CREG1 →	-2.830	-0.295	.007	.002	2	5
BLOOD_Myeloma	PRDM8 →	+0.438	+0.236	.004	.004	3	4
BLOOD_Myeloma	NEIL2 →	+1.433	+0.236	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032480 vs ARL2 — URINARY_TRACT

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