Endoplasmic reticulum calcium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum calcium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, CD74, and CD86, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum calcium ion homeostasis activity versus FCGR2A in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR2A →	+0.728	+0.160	<.001	<.001	3	6
LSCC	CD74 →	+0.670	+0.183	<.001	<.001	3	5
GBM	CD86 →	+0.611	+0.119	<.001	.004	3	5
GBM	TYROBP →	+0.797	+0.173	<.001	.001	3	5
LSCC	CSE1L →	-0.463	-0.175	<.001	<.001	3	5
LSCC	TRAP1 →	-0.416	-0.197	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032469 vs FCGR2A — GBM

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