Endoplasmic reticulum calcium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum calcium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM200A, ASF1B, and ICAM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM200A grouped by Endoplasmic reticulum calcium ion homeostasis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FAM200A →	-1.230	-1.502	.002	<.001	3	4
OESOPHAGUS	ASF1B →	-0.975	-0.681	.001	.005	3	4
OVARY	ICAM2 →	-1.990	-0.838	.004	.003	3	3
OVARY	TAF3 →	-0.396	-0.835	.009	.003	3	3
OVARY	KTI12 →	-0.670	-1.260	<.001	<.001	3	3
SOFT_TISSUE	RRAS2 →	-0.937	-0.921	.004	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM200A by Endoplasmic reticulum calcium ion homeostasis activity — URINARY_TRACT

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