Positive regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R14C, NXPH3, and CEP78, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytokinesis activity versus PPP1R14C in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPP1R14C →	+1.542	+0.661	.003	.003	3	5
CCRCC	NXPH3 →	+0.385	+0.461	.009	.002	3	4
BRCA	CEP78 →	+0.365	+0.589	.002	.008	3	4
LSCC	TBC1D31 →	+0.484	+0.887	.001	<.001	3	4
LSCC	ARHGEF6 →	-0.433	-0.752	<.001	<.001	3	4
LSCC	LRR1 →	+0.349	+0.545	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032467 vs PPP1R14C — BRCA

Explore this scatter interactively →