Positive regulation of cytokinesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDN1, GGA3, and MOB3C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDN1 grouped by Positive regulation of cytokinesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MDN1 →	-0.862	-0.219	.002	.006	3	5
BONE	GGA3 →	-0.830	-0.348	<.001	<.001	3	4
SKIN	MOB3C →	+0.493	+0.197	.002	.001	3	4
SKIN	CASP4 →	+0.684	+0.168	.005	.007	3	4
SKIN	LASP1 →	+0.651	+0.165	<.001	.008	3	4
KIDNEY	IRF1-AS1 →	+1.041	+0.197	.005	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDN1 by Positive regulation of cytokinesis activity — PANCREAS

Explore this box plot interactively →