Positive regulation of cytokinesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF653, DCLRE1B, and DHX32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytokinesis activity versus ZNF653 in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF653 →	+0.635	+0.224	.005	.001	3	5
PANCREAS	DCLRE1B →	+0.947	+0.196	<.001	.009	3	4
KIDNEY	DHX32 →	+0.547	+0.235	.001	.005	3	4
KIDNEY	MRM2 →	+1.080	+0.398	.002	.001	3	4
BLOOD_Lymphoma	GEMIN4 →	+0.823	+0.189	<.001	.009	3	4
SKIN	FAM107B →	-0.965	-0.124	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032467 vs ZNF653 — BLOOD_Lymphoma

Explore this scatter interactively →