Negative regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA6B, TNFSF8, and CHCHD7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytokinesis activity versus SEMA6B in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEMA6B →	-0.465	-0.553	.005	<.001	3	3
UCEC	TNFSF8 →	-0.636	-0.858	<.001	<.001	3	3
PDAC	CHCHD7 →	+0.206	+0.267	.004	<.001	3	3
UCEC	CLNK →	-0.500	-0.792	.001	.001	3	3
BRCA	SETBP1 →	-0.777	-0.811	.003	<.001	3	3
UCEC	PPP1R32 →	-0.862	-0.700	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032466 vs SEMA6B — OV

Explore this scatter interactively →