Negative regulation of cytokinesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS4A, TANGO6, and RNF166, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytokinesis activity versus VPS4A in LUNG_SCLC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VPS4A →	+0.664	+0.813	<.001	<.001	3	7
LUNG_NSCLC_LUAD	TANGO6 →	+1.057	+0.836	<.001	.002	3	7
STOMACH	RNF166 →	+0.872	+1.449	.001	.004	3	6
LUNG_SCLC	TERF2IP →	+1.261	+1.253	.007	<.001	3	6
LUNG_SCLC	CYB5B →	+0.851	+0.829	.001	.008	3	6
LARGE_INTESTINE	LAMA3 →	-2.598	-0.880	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032466 vs VPS4A — LUNG_SCLC

Explore this scatter interactively →