Regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAX, TRANK1, and ERN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytokinesis activity versus ITGAX in LSCC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGAX →	-0.824	-1.669	.003	<.001	3	4
BRCA	TRANK1 →	-0.592	-0.519	<.001	<.001	3	4
HNSC	ERN1 →	-0.814	-0.955	.002	.001	3	4
LSCC	TADA1 →	+0.650	+1.038	.001	.009	3	4
LSCC	APOE →	-0.882	-1.255	.004	.001	3	4
LSCC	NCF1 →	-0.643	-1.265	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032465 vs ITGAX — LSCC

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