Regulation of cytokinesis

Across TCGA cell cohorts, RNA activity of the Regulation of cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, CENPF, and KIF14, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytokinesis activity versus CENPI in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CENPI →	+1.478	+0.063	<.001	<.001	3	20
BONE	CENPF →	+1.878	+0.086	.003	.009	3	19
BONE	KIF14 →	+1.260	+0.096	.005	.002	3	19
BONE	CIT →	+1.681	+0.105	<.001	.002	3	19
BLOOD_Myeloma	KIF2C →	+1.600	+0.066	.002	.005	3	19
BONE	CENPE →	+1.410	+0.091	<.001	.006	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032465 vs CENPI — PANCREAS

Explore this scatter interactively →