Regulation of protein oligomerization

Across TCGA patient cohorts, RNA activity of the Regulation of protein oligomerization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JMJD6, UBE2O, and PRPSAP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein oligomerization activity versus JMJD6 in OV (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	JMJD6 →	+0.315	+0.051	.001	.001	3	8
UCEC	UBE2O →	+0.240	+0.104	.002	.001	3	7
BRCA	PRPSAP1 →	+0.310	+0.057	<.001	<.001	3	6
BRCA	GGA3 →	+0.193	+0.032	<.001	.006	3	6
LSCC	TRIM47_S588 →	+0.410	+0.078	.002	<.001	3	5
BRCA	ACOX1 →	+0.605	+0.047	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032459 vs JMJD6 — OV

Explore this scatter interactively →