Regulation of protein oligomerization

Across TCGA cell cohorts, RNA activity of the Regulation of protein oligomerization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, DNAL1, and SLC38A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP16 grouped by Regulation of protein oligomerization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DUSP16 →	+0.550	+0.766	.002	.005	3	5
LUNG_NSCLC_LUAD	DNAL1 →	-0.536	-1.015	.003	.001	3	5
LIVER	SLC38A6 →	-1.118	-1.303	<.001	.005	3	4
BREAST	ZNF462 →	-0.855	-0.682	.001	.002	3	4
BREAST	NECAP2 →	-0.806	-0.838	<.001	.006	3	4
BREAST	HACD1 →	-2.745	-0.862	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP16 by Regulation of protein oligomerization activity — SKIN

Explore this box plot interactively →