Endocytic recycling

Across TCGA patient cohorts, RNA activity of the Endocytic recycling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, RPS2, and RPL11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytic recycling activity versus MAP1B in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP1B →	+0.333	+0.037	.001	<.001	3	7
BRCA	RPS2 →	-0.222	-0.030	.001	.001	3	5
BRCA	RPL11 →	-0.231	-0.029	<.001	.002	3	5
BRCA	RPL4 →	-0.451	-0.031	<.001	<.001	3	5
BRCA	RPS24 →	-0.349	-0.030	<.001	<.001	3	5
BRCA	BSG →	-0.361	-0.020	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032456 vs MAP1B — GBM

Explore this scatter interactively →