Endocytic recycling

Across TCGA patient cohorts, RNA activity of the Endocytic recycling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18B, R3HDM1, and ZRANB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytic recycling activity versus KIF18B in LUAD (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF18B →	-0.868	-0.136	.003	.005	3	5
HNSC	R3HDM1 →	-0.469	-0.108	.001	.002	2	6
LSCC	ZRANB3 →	-0.500	-0.130	<.001	.001	3	5
COAD	PTBP1 →	-0.482	-0.218	.001	<.001	3	4
LUAD	NCAPH →	-0.698	-0.135	.001	.003	3	4
LUAD	HJURP →	-1.041	-0.146	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032456 vs KIF18B — LUAD

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