Endocytic recycling

Across TCGA cell cohorts, RNA activity of the Endocytic recycling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD4, MLXIPL, and YDJC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytic recycling activity versus EHD4 in LUNG_NSCLC_LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EHD4 →	+0.566	+0.149	.004	<.001	3	6
LIVER	MLXIPL →	-2.815	-0.264	.001	.001	3	5
STOMACH	YDJC →	-1.047	-0.233	.001	.001	3	5
STOMACH	CES3 →	-2.260	-0.171	<.001	.002	3	5
LIVER	BORCS7 →	-0.747	-0.281	.005	.002	3	5
SOFT_TISSUE	IMPA2 →	-1.794	-0.243	.008	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032456 vs EHD4 — LUNG_NSCLC_LUAD

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