Positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP2, ZYX, and C1QB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus MMP2 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MMP2 →	+0.775	+0.034	<.001	<.001	3	6
COAD	ZYX →	+0.356	+0.034	<.001	<.001	3	6
COAD	C1QB →	+0.672	+0.033	<.001	<.001	3	6
COAD	C1QC →	+0.783	+0.036	<.001	<.001	3	6
CCRCC	C1S →	+0.614	+0.038	<.001	<.001	3	6
COAD	COG3 →	-0.196	-0.020	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032436 vs MMP2 — OV

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