Positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLCA2, PBX1-AS1, and LINC02827, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus COLCA2 in HNSC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COLCA2 →	-0.710	-0.150	<.001	<.001	3	5
HNSC	PBX1-AS1 →	-0.632	-0.135	.006	.001	3	4
HNSC	LINC02827 →	-0.598	-0.092	.001	.007	3	4
HNSC	ADD2 →	-0.906	-0.158	.003	<.001	3	4
UCEC	CACNA1I →	-0.603	-0.151	.005	.003	3	4
LSCC	CLDN8 →	-0.995	-0.074	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032436 vs COLCA2 — HNSC

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