Positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENO1, CYP20A1, and ZNF281, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENO1 grouped by Positive regulation of proteasomal ubiquitin-dependent protein catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ENO1 →	-1.368	-0.212	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CYP20A1 →	-0.976	-0.206	.004	.001	3	5
LIVER	ZNF281 →	-0.729	-0.137	.005	.008	2	6
LARGE_INTESTINE	PLEKHH1 →	+1.297	+0.179	<.001	<.001	3	5
BREAST	CDC25B →	-0.741	-0.106	.001	.002	3	5
BLOOD_Myeloma	LY6E →	+2.734	+0.129	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENO1 by Positive regulation of proteasomal ubiquitin-dependent protein catabolic process activity — STOMACH

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