Positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY96, LAMP1, and SGCB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus LY96 in LUNG_NSCLC_LUSC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LY96 →	+2.129	+0.294	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	LAMP1 →	-0.669	-0.156	.001	.009	3	5
BREAST	SGCB →	-1.629	-0.178	.007	.005	2	5
BREAST	LDAH →	+1.597	+0.193	<.001	<.001	3	4
BREAST	LAMC1 →	-1.809	-0.186	.001	.007	3	4
BONE	RUSC2 →	-1.024	-0.250	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032436 vs LY96 — LUNG_NSCLC_LUSC

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