Negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOB1, HSPE1, and SCLY, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus NOB1 in CNS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NOB1 →	+0.543	+0.246	.003	.008	2	9
PANCREAS	HSPE1 →	+1.112	+0.405	<.001	<.001	3	7
PANCREAS	SCLY →	+1.036	+0.328	<.001	.002	2	8
LARGE_INTESTINE	SAAL1 →	+0.675	+0.217	.005	.003	3	7
OVARY	ADSL →	+0.949	+0.332	<.001	<.001	3	6
OESOPHAGUS	EEF1B2 →	+1.153	+0.228	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032435 vs NOB1 — CNS

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