Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX17, TNRC6B, and TRIP11, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus DDX17 in UVM (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DDX17 →	+1.367	+0.055	<.001	<.001	3	33
DLBC	TNRC6B →	+0.885	+0.052	<.001	<.001	3	33
UVM	TRIP11 →	+1.464	+0.055	<.001	<.001	3	33
UVM	SMCHD1 →	+1.558	+0.054	<.001	<.001	3	33
UVM	ALG13 →	+1.230	+0.056	<.001	<.001	3	33
UVM	DDX55 →	+1.393	+0.054	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032434 vs DDX17 — UVM

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