Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, COL1A2, and PRG4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus UCHL1 in UCEC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UCHL1 →	+1.076	+0.059	<.001	.002	3	6
COAD	COL1A2 →	+0.828	+0.030	<.001	<.001	3	6
CCRCC	PRG4 →	+0.648	+0.035	<.001	<.001	3	6
COAD	COL3A1 →	+0.775	+0.030	<.001	<.001	3	5
OV	DAB2 →	+0.511	+0.049	<.001	<.001	3	5
COAD	MMP2 →	+0.593	+0.027	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032434 vs UCHL1 — UCEC

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