Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, ARMC6, and TGFB2-AS1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus CD47 in BRCA (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD47 →	-0.790	-0.282	.003	.003	3	2
PDAC	ARMC6 →	+0.598	+0.215	.002	.007	3	2
PDAC	TGFB2-AS1 →	-0.580	-0.189	<.001	.005	3	2
OV	TIMM9 →	+0.462	+0.171	<.001	<.001	3	2
COAD	PLEKHJ1 →	+0.406	+0.173	.001	<.001	3	2
COAD	ILVBL →	+0.422	+0.120	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032434 vs CD47 — BRCA

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